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INDICATIONS: TYMLOS is a prescription medicine used to treat osteoporosis in men and postmenopausal women who are at high risk for fracture. See more

TYMLOS is a prescription medicine used to:

  • Treat osteoporosis in postmenopausal women who are at high risk for bone fracture, or who cannot use another osteoporosis treatment or other osteoporosis treatments did not work well. TYMLOS can decrease the chance of having a fracture of the spine and other bones in postmenopausal women with thinning and weakening bones (osteoporosis).
  • Increase bone density in men with osteoporosis who are at high risk for bone fracture, or who cannot use another osteoporosis treatment or other osteoporosis treatments did not work well.

It is not known if TYMLOS is safe and effective for children and young adults 18 years and younger. TYMLOS should not be used in children and young adults whose bones are still growing. Close

Not actual patient

Osteoporosis constantly
robs you of bone!

TYMLOS can help you stand up to
osteoporosis by rebuilding bone

Middle-aged woman smiling at camera with her arms folded across her chest. Not actual patient

For men and postmenopausal women
with osteoporosis at high risk for fracture

For men and postmenopausal women
with osteoporosis at high risk for fracture

People lose bone as they age, but osteoporosis speeds that up*

When osteoporosis occurs, more bone is being removed than added leading to a reduction in bone density

Our bones are in a constant cycle of repair, where damaged bone is removed and new bone is added. Osteoporosis occurs when more bone is being removed than added, leading to bone loss and an increased risk of fracture.

There is no cure for osteoporosis, so you should work with your doctor to find the right medications and lifestyle choices to help prevent additional bone loss or maintain your existing bone density.

*Not everyone will develop osteoporosis as they age.

How is osteoporosis measured?

Osteoporosis is mainly measured by a DEXA scan, which is a non-invasive imaging test that determines your bone mineral density (BMD). TYMLOS may increase BMD, but it also allows bone to be removed the way the body is designed to, helping to rebalance the natural bone-building process.

TYMLOS MOA graphic portraying bone-forming cells adding new bone, and bone-removing cells removing old, damaged bone.
Artistic representation, not images of real bone.
For illustrative purposes only.

Did you know TYMLOS rebalances the natural bone-building process?†

Learn more about how TYMLOS works to rebuild bone.

Explore how TYMLOS adds to the bone

†An 18-month study of daily TYMLOS administration in postmenopausal women with osteoporosis at high risk for fracture and a 12-month study of daily TYMLOS administration in men with osteoporosis at high risk for fracture showed an increase in the bone formation marker and, to a lesser extent, the bone resorption marker.

How is osteoporosis different for men and women?

While it’s almost taken for granted as a potential health challenge for women, osteoporosis in men is no myth—men actually make up 20% of people with osteoporosis.

Strategic intervention is key

Osteoporosis is top of mind for women as they age, for good reason: Estrogen, which is essential for healthy bones, drops sharply following menopause, which in turn can rapidly decrease bone density. If this decrease results in osteoporosis, it’s critical to address it strategically in order to reduce fracture risk and maintain bone health.

Not everyone will develop osteoporosis as they age.

Worldwide, osteoporosis affects
1 in 3 women over the age of 50

1 in 2 women over 50 will
break
a bone due to osteoporosis

Women who have had
1 fracture due to
osteoporosis are
5x more likely to have another

See how TYMLOS reduced fracture risk and increased BMD in postmenopausal women

Explore data in women

Male osteoporosis is a serious health risk, and it’s often missed

In the United States alone, more than 2 million men already have osteoporosis, and another 12 million are at risk. Even so, male osteoporosis remains underdiagnosed and undertreated. In fact, most men don't know they have osteoporosis until they break a bone.

Men can stand up to osteoporosis through early diagnosis and appropriate treatment. Talk to your doctor today!

Not everyone will develop osteoporosis as they age.

1 in 4 men over 50 will
break a
bone due to osteoporosis

Only 5% of men were tested for
osteoporosis after a hip facture

Only 8% of men were prescribed
a
treatment for osteroporosis

See how TYMLOS helped men rebuild bone and increase BMD

Explore data in men

How you treat osteoporosis matters, including the order of treatment

Icon: Three plus signs indicating increased rate of rebuilding new bone
Anabolic options, like TYMLOS

For postmenopausal women with osteoporosis at high risk for fracture, professional guidelines recommend starting with anabolic treatment like TYMLOS to rebuild new bone that can be maintained with an antiresorptive as follow-up treatment.

Icon: Three arrows pointing down indicating a slowing rate of bone loss
Antiresorptive options

Once you’ve built new bone, an antiresorptive can help you keep it. These medicines slow the cells that break bone down—helping to protect and preserve the bone you’ve rebuilt.

Simply slowing bone loss may not be enough

Rebuild bone with TYMLOS, then work with your doctor on how to protect it with an antiresorptive. Ask your doctor if a bone-building anabolic option is the right first step in your osteoporosis treatment plan.

Talk about TYMLOS icon

Ready to talk about TYMLOS with your doctor?

If you’re at a high risk for fracture due to osteoporosis, we can help start the conversation

Download our Discussion Guide (opens in a new tab)
TYMLOS folded leaflet

Get our patient brochure

Learn more about treating osteoporosis with TYMLOS

Download (English) (opens in a new tab)Download (Español) (opens in a new tab)

IMPORTANT SAFETY INFORMATION

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TYMLOS?

TYMLOS may cause serious side effects including: Possible bone cancer (osteosarcoma). During animal drug testing, TYMLOS caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take TYMLOS will have a higher chance of getting osteosarcoma.

  • Tell your healthcare provider right away if you have pain in your bones, pain in any areas of your body that does not go away, or any new or unusual lumps or swelling under your skin that is tender to touch.

Do not take TYMLOS: if you had an allergic reaction to abaloparatide or any of the other ingredients in TYMLOS. The inactive ingredients in TYMLOS are phenol, sodium acetate trihydrate, acetic acid, and water for injection.

Before you take TYMLOS, tell your healthcare provider about all of your medical conditions, including if you:
  • have Paget’s disease of the bone or other bone disease.
  • have or have had any of the following: cancer in your bones; radiation therapy involving your bones; too much calcium in your blood; or an increase in your parathyroid hormone (hyperparathyroidism).
  • will have trouble injecting yourself with the TYMLOS pen and do not have someone who can help you.
  • are pregnant or plan to become pregnant, because TYMLOS is not for pregnant women, or if you are breastfeeding or plan to breastfeed. It is not known if TYMLOS passes into your breast milk; you should not take TYMLOS and breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TYMLOS?
TYMLOS can cause serious side effects including:
  • Decrease in blood pressure when you change positions. Some people may feel dizzy, have a faster heartbeat, or feel lightheaded soon after the TYMLOS injection is given. These symptoms generally go away within a few hours. Take your injection of TYMLOS in a place where you can sit or lie down right away if you get these symptoms. If your symptoms get worse or do not go away, stop taking TYMLOS and call your healthcare provider.
  • Increased blood calcium (hypercalcemia). TYMLOS can cause some people to have a higher blood calcium level than normal. Your healthcare provider may check your blood calcium before you start and during your treatment with TYMLOS. Tell your healthcare provider if you have nausea, vomiting, constipation, low energy, or muscle weakness. These may be signs there is too much calcium in your blood.
  • Increased urine calcium (hypercalciuria). TYMLOS can cause some people to have higher levels of calcium in their urine than normal. Increased calcium may also cause you to develop kidney stones (urolithiasis) in your kidneys, bladder, or urinary tract. Tell your healthcare provider right away if you get any symptoms of kidney stones which may include pain in your lower back or lower stomach area, pain when you urinate, or blood in your urine.

The most common side effects of TYMLOS in women with postmenopausal osteoporosis include: dizziness, nausea, headache, fast heartbeat, feeling tired (fatigue), upper stomach pain, and spinning feeling (vertigo).

The most common side effects of TYMLOS in men with osteoporosis include: redness at injection site, dizziness, joint pain, swelling at injection site, pain at injection site, bruising, abdominal bloating, diarrhea, nausea, abdominal pain, and bone pain.

These are not all the possible side effects of TYMLOS. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

How should I use TYMLOS?
  • Read the complete Instructions for Use (opens in a new tab) provided with your medicine.
  • If you take more TYMLOS than prescribed you may experience symptoms such as muscle weakness, low energy, headache, nausea, dizziness (especially when getting up after sitting for a while), and a faster heartbeat. Stop taking TYMLOS and call your healthcare provider right away.
  • You should not use TYMLOS for more than 2 years over your lifetime.

Please read the full Prescribing Information (opens in a new tab), including Medication Guide (opens in a new tab).